Prescription opioid pain relievers are essential to improving the quality of life for millions of Americans living with acute or chronic pain. Unfortunately, misuse, diversion, addiction and overdose of these drugs has created a serious public health epidemic in the United States. Since 1999 more than 760,000 people have died from an opioid overdose (107,622 overdose deaths in 2021). Opioids, primarily prescription pain relievers, heroin, and fentanyl, are the primary drugs associated with these deaths.

This public health crisis touches ALL regions of the country, socioeconomic groups, and ethnicities. The federal government and the Food & Drug Administration (FDA) have intensified efforts to ensure safer prescribing of opioids. CO*RE provides continuing education to healthcare professionals for safe opioid prescribing in alignment with the FDA’s mission, following the FDA Blueprint (September, 2018).   

Citation:  http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6450a3.htm?s_cid=mm6450a3_w and http://www.cdc.gov/drugoverdose/epidemic/index.html


Since 2012 CO*RE has delivered in-person and online Opioid Analgesics REMS education, to more than 300,000 clinicians via more than 600 CE/CME activities (through November 2022).

Our CO*RE collaborative uses Planned Change Assessment (PCA)® as a way to measure intended and completed changes in clinical practice following an educational experience. Through the PCA process, we gather information immediately following the event via questionnaire, 4-8 weeks after the event via survey, and up to six months after the event via follow-up interviews. Here is a sampling of data from CO*RE activity participants:


This graph shows the completed changes reported from our participants. 92% of those surveyed indicate they had completed specific changes in practice.


Although the CO*RE content is intended for opioid analgesic prescribers, there are many professionals on the healthcare team who impact patient care and influence opioid therapy. This graph shows a range of important roles among prescribers and non-prescribers.


Here’s what people have to say about their experience:

“I like the videos of other healthcare providers having the difficult conversation with a patient – good modeling!”

– Physician

“The best CE I have completed so far. Thank you. Very clear but also very thorough – which is a tough balance to achieve. Thanks!”

– Nurse Practitioner

“One of the best activities of this sort I’ve seen.”

– Physician

“I was so encouraged by what I heard that I intend to overcome my own discouragement and make time to work this into my treatment of pain patients. I will re-evaluate my decision to stop treating chronic pain.”

– New Mexico Clinician


This educational activity is supported by an independent educational grant from the Opioid Analgesic REMS Program Companies (RPC). This activity is intended to be fully compliant with the Opioid Analgesic REMS education requirements issued by the U.S. Food and Drug Administration. Click here for more information about the Opioid Analgesics REMS.